Cerebral nocardiosis is an extremely rare and serious disease that mainly affects immunocompromised adults. Due to the non-specific clinical symptoms and difficult and long diagnostics, the diagnosis is often made late, often resulting in serious complications and patient's death. The case report presented below concerns a young patient whose complete recovery was achieved thanks to an accurate diagnosis and quick initiation of targeted treatment. The study aimed to present a rare infectious disease, drawing attention to the value of bacterioscopic examination and the special need for cooperation between a clinician, a microbiologist and a radiologist.