Central nervous system (CNS) toxoplasmosis represents one of the most common opportunistic complications in patients with advanced HIV/AIDS infection. A wide range of neurological symptoms may contribute to the clinical presentation of the disease. This paper reports the case of a 29-year-old man with untreated HIV infection, in whom neurotoxoplasmosis led to rapidly progressive, bilateral sensorineural hearing loss and severe disability. Appropriate neuroimaging diagnostics enabled the initiation of effective treatment; however, neurological sequelae, including hearing impairment, persisted. To the best of our knowledge, this type of complication has not been previously described in patients living with HIV and CNS toxoplasmosis.